Self-Publishing: Carnival of the Indies Issue #27 ? The Book Designer

Welcome to this issue of the Carnival of the Indies blog carnival. This issue is for December, 2012. We welcome your submissions on topics related to writing, self-publishing, book design or marketing books.

A collection of outstanding articles recently posted to blogs, your reading here will be richly rewarded.

See the end of this post for links to submit your blog posts for the next carnival, or for participating Bloggers and Featured Bloggers to grab your sidebar badges. Thanks to everyone who participated.

Featured Posts

Anne Hill presents An author-centric map of publishing posted at oreilly.com, saying, ?What would the publishing ecosystem look like if we placed authors at its center? A discussion of content, distribution, and why ?author platform? is a misleading term.?

Sarah Bolme presents Trends in Book Discovery posted at Marketing Christian Books. ?Physical bookstores are shrinking. e-Reading is on the rise. These changes are affecting how people learn about books and how they buy and read them.?

Toni @ Duolit presents Authors Who Say ?I Don?t Have Enough Time for Promotion? Are Doomed to Fail posted at Duolit, saying, ?Setting aside time for promotion is essential to your success as an indie author, but you don?t have to slave over your computer for hours at a time to see positive results. In this post, I introduce the ?Bowflex? Method: marketing for 30 minutes a day, 4 times a week!?

Book Design and Production

Loretta Boyer McClellan presents Book Cover Design and Typography 101 posted at Misthaven of Maine

J.M. Ney-Grimm presents Cover Design Primer posted at J.M. Ney-Grimm, saying, ?Basic design principles for indies seeking something simpler than a PhD in typography. Grin!?

India Drummond presents Formatting for CreateSpace posted at India Drummond ? Author, saying, ?An article and video tutorial on how to take your manuscript and produce a CreateSpace-ready PDF file without using templates. These are the steps covered in the tutorial: ?Step 1: Setting the proper page layout/margins for print books ?Step 2: Adding images ?Step 3: Formatting text using Word?s Styles options ?Step 4: Adding attractive page numbering ?Step 5: Saving your file ?Step 6: Inspecting your work for errors?

Sally Harris presents How to Hire an Illustrator posted at Frankly Books, saying, ?Hiring an illustrator as anIndie Author doesn?t have to be difficult! Here are 10 steps that help to make the process straightforward and enjoyable.?

Dave Bricker presents Proposed Standards for Book Typography posted at The World?s Greatest Book, saying, ?With type being butchered by big and small publishers alike, how do we establish criteria for professional standards in book typography? Though economic costs and benefits are easy to assess, writers and publishers should be able to evaluate aesthetic compromises based on a set of typographic best practices.?

Marcy Kennedy presents What Type of Edit Does Your Book Need? posted at Marcy Kennedy?s Blog, saying, ?I?ve noticed a lot of confusion lately about the types of edits a manuscript might need to go through before it goes out into the world, so I wrote this post to help clarify.?

Jennifer Lynn Alvarez presents Why Your Word Count Matters posted at The Jennifer (Author) Diaries, saying, ?Out of whack word counts can alienate your readers?.find out how!?

Ebooks and Ebook Readers

Mike Reeves-McMillan presents 60 (or more) Indie Books Worth Reading posted at The Gryphon Clerks, saying, ?From anIndie Author (and harsh reviewer), a list of indie books worth reading.?

Jane Ayres presents E-books and writing for children posted at The Beautiful Room, saying, ?This post charts my experiences and problems marketing e-books for pre-teens and asks questions about how to tackle the issues specific to e-books for this age group.?

Indie Author

Ben Z presents How to write about King Arthur, Camelot, Excalibur and Merlin. Feel chivalrous. posted at ben zackheim, blogben zackheim, blog, saying, ?Here, I reflect on the experience of writing a story based in the Camelot lore. It was a hard six-year slog through age-old misconceptions of the original stories, stodgy feedback from scholars, and, ultimately, self-discovery. In the end I got a book that I love, and a sense of what chivalry and kindness is.?

James Moushon presents Book Author: An interview with Rayne Hall posted at eBook Author?s Corner, saying, ?An interview with short story author Rayne Hall.?

David Bergsland presents Formatting your books & ebooks: DIY or Paid? posted at The Skilled Workman, saying, ?This is 1500 words examining the questions all indie writers face as they publish their books. What do you want to do and what do you want to pay others to do for you??

Patty Jansen presents How much does self-publishing cost? posted at Must Use Bigger Elephants, saying, ?This post was sparked by my annoyance at ?partnership? aka ?vanity? presses who peddle promotional packages to unsuspecting n00b authors.?

Alexander M Zoltai presents I Need Your Help ~ Let?s Decide Which Is Better: Traditional or Self-Publishing . . . posted at Notes from An Alien, saying, ?Weigh-in with your comments _ Which Is Better?Traditional or Self-Publishing??

Laura Pepper Wu presents Q&A with Guy Kawasaki, author of APE: Author, Publisher, Entrepreneur? How to Publish a Book. posted at 30 Day Books, saying, ?Guy Kawasaki is a New York Times Bestseller, co-founder of Alltop.com and former chief evangelist for Apple. He?s published both traditionally and independently and is now pushing ?artisinal self-publishing? in his new book APE: Author, Publisher, Entrepreneur. In this short Q&A, I got to pick his brains about his thoughts on successful independent publishing and garnered his tips on how to create buzz for a book.?

iWriteReadRate.com presents Reaching Readers & Breaking Through The Indie Noise posted at The iWriteReadRate Blog, saying, ?It?s a crowded, busy and noisy place out there in the new world of digital publishing. Here?s some thoughts from iWriteReadRate Founder, Adam Charles, on what?s happening and what you should think about as an Indie Author??

Chris Kridler presents What genre is your book? Your readers may decide posted at Sky Diary ? ChrisKridler.com, saying, ?Even if you think you know your genre, readers have their own ideas of what adventures, romances and other novels should be, and their perceptions and reviews will affect how others see your work.?

Aishah Macgill presents Where Is Your Special Writing Place posted at Aishah Macgill, saying, ?Where do you mostly sit and write? Is it the right place for you? Maybe think outside the square and try a few funky places. You might be pleasantly surprised at how your creativitiy and volume of writing goes sky high!?

Kaz Augustin presents Why some self-publishers aren?t posted at Sandal Press blog, saying, ?I don?t think the line connecting self-publishing and small business has been drawn heavily enough. This is my post in reply to April Hamilton?s (Publetariat.com) on ?Indie Entrepreneurs?.?

Diana Jackson presents Writing a Memoirs ~ The Joys and Pitfalls posted at Diana Jackson?s Muse, Views and Reviews, saying, ?Useful and at times poignant advice for anyone attempting to write a memoirs. Questions to ask before you start: Is it only for family members and friends? Is it commercially viable? Will you self publish or find a publisher? What equipment will you need? Above all, enjoy every moment and be ready for a unique experience!?

Gary Gauthier presents Composition 101 posted at Literary Snippets, saying, ?Like the composer of music, the goal of the writer is to create a final piece that develops its theme harmoniously and can stand on its own merit.?

Marketing and Selling Your Books

M. Louisa Locke presents Authors Need to Get a Clue: How to devise the best marketing strategy for the Holidays posted at M. Louisa Locke?s Front Parlor

Randy Ross presents Book Marketing: Tired of Banging Your Head Against the Web Wall? posted at The Loneliest Planet, saying, ?Does book marketing feel like you?re banging your head against a wall? New evidence that you are ? and some options ? that don?t involve social media.?

James Moushon presents Book Trailers: Do Authors Get Enough Bang for Their Buck? posted at eBook Author?s Corner, saying, ?highlighted on your weekly blog.?

Laura Pepper Wu presents Creating blog posts & promo materials with Piktochart posted at 30 Day Books, saying, ?I came across this great tool to help you create infographs quickly, easily and super inexpensively. You can use it to help promote your book on sites like Facebook or Pinterest. You can also use it to create quick blogposts! It?s called Piktochart, and here are some example infographs I?ve made with it.?

James Moushon presents Free Books: Give it away. Just give it away. posted at eBook Author?s Corner, saying, ?Comments from 19 authors about their experiences with ?Free Book Promotions? plus a little planning and guidance.?

Gordon Burgett presents Getting our bond book out first, fast, and often as ebooks posted at Gordon Burgett?s Blog, saying, ?While we await the arrival of our bound book from the printer, we convert and send it off to four ebook publishers so it can get posted and earn money and positioning! Details here.?

Jan Bear presents How to Write a Book Marketing Plan: Begin with the End in Mind posted at Market Your Book, saying, ?When asking how to write a book marketing plan, it?s important to start with fundamental questions that will put your book promotion into perspective.?

Jan Bear presents Too Many Books? ? Market Your Book posted at Market Your Book, saying, ?Publishing professionals tend to panic about the numbers of books being published. But that?s not the only way to look at it.?

Self-Publishing Success

C. S. Lakin presents Essential Strategic Planning for Writers?Looking Ahead to 2013 posted at Live Write Thrive, saying, ?This is part one of a five-part intensive (practical and humorous!) guide forIndie Authors to help them strategically plan their career goals for 2013 and beyond. Think True Grit??

Writing tools and tips

Matthew Hall presents How to Outline with yWriter: An Introduction to Outlineing posted at M.L. Hall, saying, ?Introduction to outlining using yWriter.?

Matt Schoenherr presents Target Marketing: Speak Directly to Your Target Audience posted at Marketing Ideas 101, saying, ?What can you do to communicate with your target market on such a core level that you?re able to speak their native language to the exclusion of the rest of the world??

David Leonhardt presents What is a ghostwriter? posted at A Ghost Writers Blog, saying, ?This question (What is a ghostwriter?) pretty much tops the questions people have about ghostwriting. In this blog post I give a very complete explanation, which I break down into three parts.?

Gordon Burgett presents Never type out the title of your blog. Here?s why? posted at Gordon Burgett?s Blog, saying, ?Woe is you if your book title and sub-title are endless and you?re writing press releases, a landing page, and more and more. Instead, put the title in code and let your computer do the typing!?

Gibson Goff presents The Perfect Way to Get Over Writer?s Block posted at Gibson Goff ? The Enlightened Traveler

Joanna Penn presents What happens after the first draft? posted at The Creative Penn, saying, ?Maybe you ?won? NaNoWriMo or maybe you have the first draft of another book in your drawer, but we all need to take the next step in the process in order to end up with a finished product ? rewriting, editing and beta readers.?

Joseph C. Kunz, Jr. presents Questions To Ask Yourself Before Writing Your Book?s Introduction posted at Kunz On Publishing, saying, ?Thank you.?

Bob Baker presents The 3 Elements of Becoming an Irresistible Writer posted at Bob Baker?s Book Promotion Blog, saying, ?There are many factors that go into the development of truly compelling writers and authors. Here I cover three elements that will make the difference between you being a mediocre writer who struggles with obscurity and a gifted wordsmith who attracts a raving fan base??

Joseph C. Kunz, Jr. presents The Preface: Share Your Inner Passion And Inspiration For Better Book Sales posted at Kunz On Publishing

Well, that wraps up this issue. I hope you enjoy some of the great articles here, and let other people interested in self-publishing know about the Carnival?Use the share buttons below to Tweet it, Share it on Facebook, Plus-1 it on Google+, Link to it! The next issue is January 27, 2013 and the deadline for submissions will be January 20, 2013. Don?t miss it! Here are all the links you?ll need:

The original announcement post
Carnival of the Indies web page
Submit your article here
Bloggers, grab your official Carnival of the Indies Badges here
Follow Carnival of the Indies on Twitter
Subscribe to The Book Designer Blog

Tagged as: Anne Hill, author platform, blog carnival, blogging, carnival of the indies, indie author, Sarah Bolme, self publishing, Toni Tesori

Source: http://www.thebookdesigner.com/2012/12/self-publishing-carnival-of-the-indies-issue-27/

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Beyond Structured Settlements: Structured Settlements in 2012 - 4

Executive Life of New York

At one time or another, each of us may have become acquainted with individuals who have overcome personal injuries and successfully transformed their disabilities and special needs into special lifetime accomplishments. Kyle Walsh, profiled in a 2012 S2KM blog post, is one such individual. The late Randy Snow, featured in a 2008 S2KM blog series, was another.

Structured settlements are supposed to provide economic security for people with serious injuries and disabilities - to help them rebuild their lives and, in many cases, to achieve special lifetime accomplishments. Instead of an all-cash personal injury settlement, structured settlement recipients accept a promise of future periodic payments.

What happens, if and when, that promise is broken? What happens when a structured settlement funding company, and the regulators and guaranty system responsible for protecting the structured settlement recipients, fail to make and/or insure full payment?

These questions are highlighted by the Executive Life of New York (ELNY) liquidation - the dominant structured settlement story of 2012 and one of the most important developments in the history of the United States structured settlement industry.

The story of ELNY, as well as its affiliate Executive Life of California (ELIC), and their parent company, First Capital Corporation (FEC), is long and complex. For background of events prior to ELNY's 1991 receivership, S2KM recommends Gary Schulte's 1992 book "The Fall of First Executive".

Significantly, neither the 1991 ELNY Rehabilitation Order nor the 1992 Order approving the ELNY Rehabilitation Plan declared ELNY to be insolvent. When then New York's Insurance Commissioner Salvatore Curiale seized control of ELNY on April 16, 1991 and placed it in receivership, he stated: "The company is currently neither in an insolvent or impaired condition. . . . I have not petitioned the Court to make a finding of insolvency. ELNY is a company well able to meet its current obligations."

Exactly twenty-one years later, on April 16, 2012, following 11 days of hearings at the Nassau County New York Supreme Court, presiding Judge John M. Galasso approved an Order of Liquidation and a Restructuring Agreement for ELNY as proposed by the Superintendent of the New York State Department of Financial Services (Superintendent), as ELNY's Receiver, and the National Organization of Life and Health Guaranty Funds (NOLHGA).

The result of the ELNY Liquidation Order and Restructuring Plan, even following contributions from state guaranty funds and voluntary life insurance company contributions, is a $900 million shortfall allocated entirely (and arguably inequitably) to more than 1400 ELNY payees out of a total of approximately 9700 current ELNY payees. The remaining ELNY payees expect to receive 100 percent of their promised future payments. The average individual shortfall is estimated to exceed $600,000 present value. Although an ELNY Hardship Fund has been created, it has not yet been funded.

An appeal was filed May 30, 2012, on behalf of 18 ELNY structured settlement shortfall payees, challenging the ELNY liquidation order and restructuring agreement on the basis of due process. The appeal also alleges that immunities and injunctions granted under the liquidation order are improper. Oral arguments occurred on November 15, 2012 in Brooklyn before the Appellate Division of the Supreme Court of the State of New York, Second Department. No decision has been announced.

Another legal challenge to the ELNY liquidation order occurred June 14, 2012 when attorneys for several liability insurers filed a Motion asking Judge John Gallasso to "clarify and/or correct" his April 16, 2012 ELNY Memorandum Decision. The motion indirectly raises the issue of whether qualified assignments extinguish the liability of defendants and/or liability insurers for shortfall payments resulting from the ELNY liquidation? Judge Galasso denied the Motion without further explanation.?

In a subsequent development, somewhat related to the liability insurers' motion, the ELNY website announced an ELNY Facilitation Plan to assist owners of ELNY structured settlement annuities (SSAs) make supplemental payments to ELNY SSA payees and to coordinate those payments with the ELNY benefit payments scheduled to be made by the Guaranty Association Benefits Company (GABC) under the ELNY Restructuring Plan approved by Judge Galasso on April 16, 2012 as part of the ELNY liquidation order.

The same attorneys who filed the ELNY appeal, Edward Stone and representatives of the Christensen & Jensen law firm, filed a class action lawsuit November 8, 2012, on behalf of ELNY shortfall victims, against Benjamin M. Lawsky, Superintendent of Financial Services of the State of New York, and his predecessor ELNY Rehabilitators, as well as MetLife and Credit Suisse. The class action allegations provide a critical litany of mismanagment and non-disclosure during the 21 years ELNY's estate was being supervised by these defendants.

In response, attorneys representing Benjamin M. Lawsky, in his capacity as ELNY's Receiver, filed a Notice of a Motion with the Nassau County New York State Supreme Court requesting oral argument on January 4, 2013 at 9:30 a.m. or as soon thereafter as the parties may be heard:

• to enjoin three ELNY structured settlement shortfall payees and their legal counsel from proceeding with a class action lawsuit in the United States District Court Southern District of New York;
• to hold in contempt of court the shortfall payees' legal counsel; and
• to require their payment of the related costs and attorney's fees incurred by the Superintendent.

Although the ELNY liquidation has so far received limited coverage in the mainstream media, specialty insurance experts and analysts have not been silent. Examples:

• Peter Bickford - In his article titled "The Elephant in the Court Room" (summarized here by S2KM), Bickford argues New York?s receivership system has failed ELNY, its policyholders and beneficiaries, as well as the insurance industry and its customers due to a lack of basic accountability standards. Although the ELNY restructuring plan may solve the immediate ELNY problem (at the expense of the remaining ELNY shortfall victims), Bickford maintains it does not address the broader, underlying systemic defects inherent in the New York life insurance receivership system. Without an act of the New York legislature, according to Bickford, "there will be no life insurance guaranty fund coverage in New York" following ELNY. Bickford's article also provides succinct summaries of objections raised by ELNY shortfall victims and ELNY legal issues which he states "could linger in the courts for years"
• LifeHealthPro - In an article titled "The Complete ELNY Saga: 21 Years of Mismanagement, Corruption, Broken Promises and Shattered Lives", (summarized here by S2KM), the authors assign primary blame for ELNY insolvency to the NYLB which they describe as "a rogue agency known for its codes of secrecy and characterized by many who spoke for this story as ineffective and mismanaged at best, and a snake pit of corruption at worst". In a companion article (reviewed here by S2KM), writer Warren Hersch asks: "is the structured settlement process in need of reform"?? In a follow-up oped article titled "Governor Cuomo I'm Calling You Out", (summarized here by S2KM), Bill Coffin, LifeHealthPro's Group Editor, charges New York Governor Andrew Cuomo with personal responsibility to clean up the "ELNY debacle".

The final results of the ELNY liquidation will depend upon the outcome of the continuing litigation highlighted in this article. It also remains to be seen what reforms, if any, will result from the failed ELNY receivership process.

In conclusion, it should also be noted that ELIC-related litigation continued in 2012 (Garamendi v. Altus Finance S.A.) when a federal jury in Los Angeles rejected a claim by California's Insurance Commissioner that, but for a conspiracy by French investor group Artemis S.A.:

• ELIC's original conservator (then California insurance commissioner John Garamendi) would have accepted an alternative bid in 1991 by state insurance guaranty associations; and
• The alternative bid would have retained profits from ELIC's junk bond portfolio for the benefit of policyholders including ELIC structured settlement recipients.

For S2KM's complete and continuing reporting about the ELNY liquidation, see the structured settlement wiki.

This blog post completes S2KM's series "Structured Settlements in 2012":

• Part 1 - Primary market
• Part 2 - Settlement planning
• Part 3 - Secondary market
• Part 4 - Executive Life of New York

Source: http://s2kmblog.typepad.com/rethinking_structured_set/2012/12/structured-settlements-in-2012-4.html

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Loans and Finance: Happy Fiscal Cliff Day

Welcome to Loans and Finance, part of www.kenfrost.com "The Living Brand".

Loans and Finance can be accessed directly via www.loanbuster.net

Loans and Finance provides up to date information and views on loans, finance, money, debt and business issues.

Source: http://loanbuster.blogspot.com/2012/12/happy-fiscal-cliff-day.html

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Internet Marketing Search Engine Optimization SEM SEO service ...

SEO will let you increase your rankings on search engines. It depends on the keywords you are using. If you want to attract more visitors to your site, you should create a website with keywords that are popular. The post below can help you come to grips with some of the complexities of SEO through some very useful tips.

Make sure to configure your server to be sensitive to capitalized letters on URLs. If not, your site could be respidered with upper and lower case letters decreasing your link ranking.

Incorporate keywords and phrases into HTML tags to improve your sites SEO. Search engines place more weight on keywords in titles than on words in the main body. Focus on the most relevant keywords.

Any articles that you contribute should always contain backlinks that are associated to your website. This is particularly prudent if your website is targeted at ezines audiences. Many time, these e-zines are archived, meaning that the articles and links are kept active almost indefinitely.

Membership in the Chamber of Commerce and Better Business Bureau will enhance your search engine optimization and increase your credibility. These organizations link to their member businesses, so you can get more local visitors. Also, if you are a part of this Better Business Bureau and have good ratings on their site, your customers will trust you even more.

You have to give keyword density some attention when optimizing pages for the search engines. No more than twenty percent of your content should consist in keywords.

Before selecting a SEO company to support your website, be certain to investigate them thoroughly. Ask solid and direct questions about their results, their success in SEO promotion, their best practices and most importantly, ask how long before you start seeing results. Also ask to see some of their previous work, and see if you can speak with some of their former clients. An upstanding, high quality company will have no problem with this.

If you include a blog on your website, you will show up more often on search engines. The amount of visitors finding you site will be on the rise.

Take advantage of the companies that provide SEO services. These companies will help you get your site a much higher search engine ranking. You can often find great deals on these services.

While pictues make a website look attractive, sites that are looking to improve their search rankings don?t concentrate on images. Only the URL is offered for the search engine index when there is an image link.

An important component of your website is an RSS feed, also known as a Really Simple Syndication feed, that can provide potential buyers with relevant updates. If RSS feeds are updated regularly, they count as fresh content. If you can?t find a suitable feed, create your own. Make sure it has relevant information for your target market. It is also wise to encourage others in subscribing to your RSS feed.

SEO takes time, so be patient. Of course you would love to realize immediate results after doing all that hard work. With millions of websites already online, it will take time for yours to fight its way to the front. You need to stay with it, even if you are not seeing any changes yet. You will reap the reward and climb the ranks in the search engine results over time with hard work and dedication.

Consider advertising products through podcasting. You can include both audio and video content in a podcast, just be sure it is content your users care about. They are growing more and more popular among consumers, and the good news is all they require is a video camera or tape recorder. Doing this will allow the description of your podcast to appear.

All of your links, incoming and internal, should use keywords. ? as your main anchor text. This will help the search engines see your links and additional keywords as being relevant, which will get you higher search rankings. Double check that all of your past content has appropriate keywords in the anchor text also.

Every page in your website needs to be easy to read. If you design a website which is easy to navigate and read, including accessibility options like making the font size larger, you?ll find that your site ranks higher on search engines. This is excellent for both your readers with impairments and disabilities, and your search ranking, as well.

Search engine optimization works by seeking out popular keywords and then applying a mathematical formula to rank the page based on these words. The highest-ranking websites are those whose keyword content closely matches a search term; you can make your website one of them by employing keywords properly. The most effective ways to use keywords are covered in this article.

Search Engine Optimization, SEO

Source: http://www.websitehostdirect.com/search-engine-optimization-guide-you-need/

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Doctoral and Postdoctoral Positions, The Max Planck Institute for the ...

The Max Planck Institute for the Study of Religious and Ethnic Diversity (Department for Socio-Cultural Diversity) is seeking to appoint

1. up to four researchers (wissenschaftliche Mitarbeiter/innen) at the doctoral and postdoctoral level
Applicants should have a degree in anthropology, sociology, political science, or geography. Applicants for the postdoctoral positions should have an excellent PhD, publications and envisage a research career.
Their research experience and publications should be relevant to the research areas of the department.
Applicants for a doctoral position should have a research project in mind for their PhD (and send a brief description of about one page), but need not have a fully developed proposal. Advanced PhD students may also apply for one- or two-year writing-up scholarships. Please note: the Max Planck Institute does not award doctorates; PhD students should independently enroll in universities. Presence at the G?ttingen institute is required.
Very good spoken and written English is required.
The successful applicants will contribute to the department?s research relating to
- social interactions in contexts of diversity,
? organisations, institutions and diversity (including e.g. cities or NGOs),
? superdiversity and its consequences.
Initial contracts will be for two years and are renewable to up to 4 years (for PhDs) and up to six years (for postdoctoral fellows). Salary will be based on the German public service scale TV?D, level E 13 (50% for PhDs). The envisaged starting date is 1 June 2013.
The deadline for electronic (one file please) or postal applications is 6 February 2013.
Applications should include a cover letter, CV, a list of publications, and the names and contact details of two potential referees. PhD applicants in particular should send a record of university courses and performance.
Interviews will be held in the first half of March 2013.

2. two one-year postdoctoral researchers
Scholars whose research relates to the substantive concerns of the department?s research programme and whose PhDs have been submitted by 1 June 2013 are eligible to apply. The fellowship is intended to provide the basis for developing a new research project or writing the PhD thesis into publications. The fellowship holders are expected to take part in the academic life of the institute.
Fellowships will begin on 1 September or 1 October 2013.
The deadline for electronic (one file please) or postal applications is 1 June 2013. Applications should include a cover letter, CV, a list of publications, a research/writing plan for the period of the fellowship and the names and contact details of two potential referees. Please also send an electronic copy of the PhD-thesis or sample chapters. These will of course be treated confidentially. Based on the guidelines of the Max-Planck Society, fellowships entail a monthly stipend of approximately ? 1.468 to ? 1.621 (German nationals) or ? 2.100 to ? 3.000 (foreign nationals). Stipends are not subject to income tax or obligatory social security contributions.
The Max Planck Society wishes to increase the participation of women wherever they are underrepresented; therefore, applications from women are particularly welcome.
Following its commitment to an equal opportunities employment policy, the Max Planck Society also especially encourages handicapped persons to submit their applications.
Applications should be sent to: Frau C. Albern, Max-Planck-Institut zur Erforschung multireligi?ser und multiethnischer Gesellschaften, Hermann-F?ge-Weg 11, D-37073 G?ttingen (per post), or electronically to VWE@mmg.mpg.de
For further details about the positions contact Prof. Dr. Karen Sch?nw?lder at schoenwaelder@mmg.mpg.de
Call: http://www.mmg.mpg.de/fileadmin/user_upload/Stellen/2012_Ausschreibungen_researchers_postdocs.pdf

This entry was posted in Job Openings. Bookmark the permalink.

Source: http://news.sisr-issr.org/?p=384

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M 3.5, Central California

Earthquake Details

• This event has been reviewed by a seismologist.

Magnitude	3.5
Date-Time
Location	36.157?N, 118.060?W
Depth	1 km (~0.6 mile) (poorly constrained)
Region	CENTRAL CALIFORNIA
Distances	13 km (8 miles) SSW (205?) from Olancha, CA 16 km (10 miles) NW (321?) from Coso Junction, CA 18 km (11 miles) S (190?) from Cartago, CA 48 km (30 miles) S (179?) from Lone Pine, CA 234 km (146 miles) N (4?) from Los Angeles Civic Center, CA
Location Uncertainty	horizontal +/- 0.3 km (0.2 miles); depth +/- 1.1 km (0.7 miles)
Parameters	Nph= 44, Dmin=30 km, Rmss=0.21 sec, Gp= 72?, M-type=local magnitude (ML), Version=1
Source
Event ID	ci15268969

• Did you feel it? Report shaking and damage at your location. You can also view a map displaying accumulated data from your report and others.

Scientific & Technical Information

---

Source: http://earthquake.usgs.gov/earthquakes/recenteqsww/Quakes/ci15268969.php

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Electric car crashes could pose new risk for first responders, group ...

CNN) ? Fuel-saving gas-electric hybrid and all-electric cars and trucks powered by sizable battery packs and high voltage motors could present a new kind of danger at serious accident scenes, according to an industry group.

A report by the Society of Automotive Engineers (SAE) highlighted risks to first responders and tow operators from potential electric shock from damaged systems not disengaged during or immediately after a crash.

?As electric vehicles enter the marketplace in greater numbers, it?s an appropriate time to recognize best practices that facilitate a safe response when these vehicles are in an accident,? said Todd Mackintosh, chairman of the SAE technical committee that issued the report earlier this month.

The group recommended automakers install switches that would kill battery power in the event of an accident. The location of those switches should be standardized for safety.

Another recommendation would create a guide for emergency workers, something Mackintosh called a ?cheat sheet for first responders.? It would quickly identify the location of high-voltage components allowing them to be disabled.

Tow truck drivers also need better information and training on how to handle hybrids and electric vehicles without receiving an unexpected jolt, the report said.

More than 435,000 battery powered electric and hybrid electric vehicles were sold in the United States this year, an increase of 53%, compared to 2011 sales numbers, according to the Electric Drive Transportation Association.

In May, auto industry officials and the National Highway Traffic Safety Administration (NHTSA) and the Energy Department discussed potential dangers faced by first responders from electrical charges produced by hybrid and electric cars.

NHTSA later issued interim guidance for consumers, emergency responders and tow truck operators to increase awareness about specific dangers.

Dangers can be reduced if responders have easy access to battery packs and if auto manufacturers create common disconnect locations in all hybrid and electric vehicles, NHTSA said.

Automakers are getting the message out to drivers and responders.

Nissan places the battery pack of its LEAF all-electric car in a steel case. The Japanese automaker also designed the battery pack to sense a crash and disable its electrical charge when involved in an accident.

Ford has published a guide for first responders encountering its Focus EV involved in accidents. The Focus EV includes what Ford calls ?Electric Badges,? which are clearly marked logos on the doors and trunk lid to warn responders of possible electric shock. Cables wrapped in orange high-voltage warning sleeves are located under the hood of the Focus EV.

General Motors, maker of the Chevy Volt, is also helping to prepare fire service and other first responders.

Moreover, GM took steps to better protect the Volt battery pack following a fire that flared after a crash test in 2011. NHTSA found no defect with the lithium-ion battery system nor were any real world crash-fires ever reported. But the case highlighted potential safety concerns for first responders.

Source: http://wtvr.com/2012/12/28/electric-car-crashes-could-pose-new-risk-for-first-responders-group-says/

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Soccer-Vilanova will be back in 15 to 20 days, say Barca

Dec 28 (Reuters) - Barcelona president Sandro Rosell says coach Tito Vilanova, who suffered a recurrence of cancer in his saliva glands earlier this month, will be back at work midway through January.

Vilanova underwent surgery on Dec. 20, a day after the club announced that the 44-year-old's condition had returned. He first had treatment in 2011.

"He'll be back within 15 or 20 days, but he must spend some days at the hospital and rest," Rosell told reporters in Dubai on Friday.

"He will mix work with his treatment. The most important thing is his health. Right now football comes second," added Rosell.

Barcelona have made a record-breaking start to their first season under Vilanova, who replaced friend Pep Guardiola at the helm at the end of the last term, by dropping only two points in 17 matches to lead La Liga by nine points.

Assistant Jordi Roura is taking charge in his absence. Barca's next league match is at home to city rivals Espanyol on Jan. 6. (Writing by Tom Pilcher, Editing by Mark Meadows)

Source: http://news.yahoo.com/soccer-vilanova-back-15-20-days-barca-215750209--sow.html

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Simple Home Improvements that Go a Long Way

Renovating your home doesn?t have to be extremely costly or time-consuming. You can change the look of any room in your house with a few simple changes. From paint color to easy decor switch-ups, it?s not difficult to create a new look.

Look at flooring as a simple renovation option. Hardwood floors are a top choice for homeowners, but they can be very expensive. Consider laminate flooring instead. You can achieve the same look, but for so much less. Laminate floors come in a wide variety of colors and designs, so no matter what overall feel your home calls for, you can find a finish that will fit perfectly.

Do-it-yourself types love the ease with which laminate floors can be installed. If you?re not the handy type, call a contractor. It will still cost quite a bit less to have laminate floors installed when compared to hardwood flooring.

Changing the paint color in a room instantly creates a new look. It?s one of the most inexpensive ways to give your home a facelift. Again, this is a task many homeowners can take on themselves or they can always hire a professional to complete it. Light colors make a room appear larger and more airy, but a contrast wall in an eye-catching color is a modern way to give a room a bit of ?pop.?

Adding ?pops? of color to a room can be as simple as changing small decor items. Pillows are a favorite, but think beyond sofa and chair pillows. Large floor pillows are practical and decorative at the same time. From luxurious materials like silk to funky patterns like animal print, you can change a room?s complete feel with the right pillow choices.

Update your home?s look with modern fixtures. Switch out cabinet pulls and doorknobs; it?s an inexpensive fix that you can do in one weekend. The same can be accomplished with new faucets and handles in the bathroom or kitchen. Look for what?s hot in home fixtures and instantly pull a room into the current decade with simple additions like these.

Window treatments are another way to change your home?s look in no time. Blinds are still popular, but drapes have never gone out of style for people who love them. Curtains are available in a huge range of shades and styles. For outdoor changes, the simple addition of shutters can give your home?s exterior a great lift.

You don?t have to endure a long and costly home renovation to give your house a new look. Whether you go for a big switch like laminate flooring or smaller touches like decorative accents, you don?t have to go broke when giving your home a makeover. Focus on one room or focus on one change like laminate on your floors. Even the simplest renovations can make a home of any age feel like new.

Source: http://viewfromthehill.org/simple-home-improvements-that-go-a-long-way/

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Health and Fitness: Back Pain ? Some Clues to Discovering the ...

--> \ '); $('#wpl-mustlogin').hide().slideDown('fast'); } ); $('#wpl-mustlogin input.input').live( 'focus', function() { $(this).prev().hide(); }).live( 'blur', function() { if ( $(this).val() == '' ) { $(this).prev().show(); } }); $('#wpl-mustlogin input#wp-submit').live( 'click', function(e) { e.preventDefault(); $.post( 'http://fyfedyfolygo.wordpress.com/wp-admin/admin-ajax.php', { 'action': 'wpl_record_stat', 'stat_name': 'loggedout_login_submit' }, function() { $('#wpl-mustlogin form').submit(); } ); }); $('#wpl-mustlogin a#wpl-signup-link').live( 'click', function(e) { e.preventDefault(); var link = $(this).attr('href'); $.post( 'http://fyfedyfolygo.wordpress.com/wp-admin/admin-ajax.php', { 'action': 'wpl_record_stat', 'stat_name': 'loggedout_signup_click' }, function() { location.href = link; } ); }); }) })(jQuery); /* ]]> */ Follow

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Source: http://fyfedyfolygo.wordpress.com/2012/12/26/health-and-fitness-back-pain-some-clues-to-discovering-the-cause/

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Source: http://jermainefaulkner.typepad.com/blog/2012/12/health-and-fitness-back-pain-some-clues-to-discovering-the.html

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Source: http://tambeoc.posterous.com/health-and-fitness-back-pain-some-clues-to-di

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Bluestacks for Mac hits beta, injects a little Google in your Apple

If you're one of those folks that like to bridge the divide -- rocking an Android handset, but rely on a Mac for heavy lifting -- we've got some good news. Bluestacks, the emulator that lets you run Android apps on your desktop has hit beta on OS X. The tool launched in beta form on Windows in March and an alpha version for Mac landed in June. Now there should be a little more parity between the major desktop ecosystems when it comes to getting your Flipboard and Bad Piggies on. To download it for yourself hit up the source link.

Filed under: Software, Apple, Google

Comments

Via: Android Central

Source: Bluestacks

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/sud4TYw84_4/

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Choosing Between Computer Science and Information Technology ...

[unable to retrieve full-text content]Most of the professionals in this field obtain jobs that deal with designing software, developing websites, designing computers or providing maintenance to computing systems and hardware. Information technology is a branch ...

Source: http://www.articleswide.com/article/12212-Choosing_Between_Computer_Science_and_Information_Technology_Engineering_Courses.html

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Video: More rain, snow on the way

Sorry, Readability was unable to parse this page for content.

Source: http://video.msnbc.msn.com/nightly-news/50300296/

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Baby Boomer Alert: #1 Hit Maker Fontella Bass Dies At 72! (VIDEO)

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She really only had one hit?but it was a doozie!

Fontella Bass, who had a monster #1 hit in 1965 called ?Rescue Me,? has died in St. Louis according to family members.? ?Rescue me? stayed at #1 for over a month and sold 1.2-million records.

Turn your speakers up and pay tribute to one of the 1960s greatest ?One Hit Wonders.?

Source: http://cnynews.com/baby-boomer-alert-1-hit-maker-fontella-bass-dies-at-72-video/

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Stunning Tabby Male Cat - Orlando Classifieds - Kijiji

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Former President George H.W. Bush in intensive care

HOUSTON (AP) ? Former President George H.W. Bush has been admitted to the intensive care unit at a Houston hospital "following a series of setbacks including a persistent fever," but he is alert and talking to medical staff, his spokesman said Wednesday.

Jim McGrath, Bush's spokesman in Houston, said in a brief email that Bush was admitted to the ICU at Methodist Hospital on Sunday. He said doctors are cautiously optimistic about his treatment and that the former president "remains in guarded condition."

No other details were released about his medical condition, but McGrath said Bush is surrounded by family.

The 88-year-old has been hospitalized since Nov. 23, when he was admitted for a lingering cough related to bronchitis after having been in and out of the hospital for complications related to the illness.

Earlier Wednesday, McGrath said a fever that kept Bush in the hospital over Christmas had gotten worse and that doctors had put him on a liquids-only diet.

"It's an elevated fever, so it's actually gone up in the last day or two," McGrath told The Associated Press. "It's a stubborn fever that won't go away."

But he said the cough that initially brought Bush to the hospital has improved.

Bush was visited on Christmas by his wife, Barbara, his son, Neil, and Neil's wife, Maria, and a grandson, McGrath said. Bush's daughter, Dorothy, was expected to arrive Wednesday in Houston from Bethesda, Md. The 41st president has also been visited twice by his sons, George W. Bush, the 43rd president, and Jeb Bush, the former governor of Florida.

Bush and his wife live in Houston during the winter and spend their summers at a home in Kennebunkport, Maine.

The former president was a naval aviator in World War II ? at one point the youngest in the Navy ? and was shot down over the Pacific. He achieved notoriety in retirement for skydiving on at least three of his birthdays since leaving the White House in 1992.

___

Plushnick-Masti can be followed on Twitter at https://twitter.com/RamitMastiAP

Source: http://news.yahoo.com/spokesman-george-h-w-bush-intensive-care-233918880.html

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Israel: No proof chemical weapons used in Syria

By NBC News staff and wire reports

JERUSALEM - Israel voiced doubt on Tuesday about claims that chemical weapons had been used against rebels fighting to topple President Bashar Assad.

Activists on Monday claimed civilians had suffered injuries consistent with exposure to some kind of poisonous gas.

"We have seen reports from the opposition. It is not the first time. The opposition has an interest in drawing in international military intervention," Vice Prime Minister Moshe Yaalon said on Army Radio.

"As things stand now, we do not have any confirmation or proof that (chemical weapons) have already been used, but we are definitely following events with concern," he said.

Syria activists: Several die after Assad's forces use 'poisonous gases'

The Syrian Observatory for Human Rights gathered activist accounts on Sunday of what they said was a poison gas attack in the city of Homs. The reports are difficult to verify, as the government restricts media access in Syria.

The Observatory, a British-based group with a network of activists across Syria, said those accounts spoke of six rebel fighters who died after inhaling smoke on the front line of Homs's urban battleground. It said it could not confirm that poison gas had been used and called for an investigation.

Syria has said it would never use chemical weapons against its citizens.

Asked about images purported to show patients being treated for possible gas poisoning, Yaalon said: "I'm not sure that what we're seeing in the photos is the result of the use of chemical weapons.

"It could be other things," he said, without elaborating.

On Sunday, senior Israeli defense official Amos Gilad said Syria's chemical weapons were still secure despite the fact that Assad had lost control of parts of the country.

As Syria's southern neighbor, Israel has been concerned about chemical weapons falling into the hands of Islamist militants or Lebanese Hezbollah fighters, cautioning it could intervene to stop such developments.?

Earlier this month, President Barack Obama warned Assad that the?use of chemical weapons by his regime would be "totally unacceptable.""If you make the tragic mistake of using these weapons there will be consequences and you will be held accountable," he said.

More world stories from NBC News:

Follow World News from NBCNews.com on Twitter and Facebook

Source: http://worldnews.nbcnews.com/_news/2012/12/25/16145639-israel-no-proof-chemical-weapon-was-used-in-syria?lite

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Firemen's killer left chilling note, deaths at 3

WEBSTER, N.Y. (AP) ? An ex-con killed two firefighters with the same caliber and make military-style rifle used in the Connecticut school massacre after typing a note pledging to burn down his neighborhood and "do what I like doing best, killing people," police said Tuesday as another body, believed to be the gunman's missing sister, was found.

William Spengler, 62, who served 17 years in prison for manslaughter in the 1980 hammer slaying of his grandmother, set his house afire before dawn Christmas Eve before taking a revolver, a shotgun and a semiautomatic rifle to a sniper position outside, Police Chief Gerald Pickering said.

The death toll rose to three as police revealed that a body believed to be the killer's 67-year-old sister, Cheryl Spengler, was found in his fire-ravaged home.

Authorities say he sprayed bullets at the first responders, killing two firefighters and injuring two others who remained hospitalized Tuesday in stable condition, awake and alert and expected to survive. He then killed himself as seven houses burned on a sliver of land along Lake Ontario.

Police recovered a military-style .223-caliber semiautomatic Bushmaster rifle with flash suppression, the same make and caliber weapon used in the elementary school massacre in Newtown, Conn., that killed 26, including 20 young children, Pickering said.

The chief said it was believed the firefighters were hit with shots from the rifle given the distance but the investigation was incomplete.

"He was equipped to go to war, kill innocent people," the chief said.

The two- to three-page typewritten rambling note left by Spengler did not reveal what set off the killer or provide a motive for the shootings, Pickering said. He called the attack a "clear ambush on first responders."

He declined to reveal the note's full content or say where it was found. He read only one chilling line: "I still have to get ready to see how much of the neighborhood I can burn down, and do what I like doing best, killing people."

Pickering said it was unclear whether the person believed to be Spengler's sister died before or during the fire.

"It was a raging inferno in there," Pickering said.

A next-door neighbor said Spengler hated his sister and they lived on opposite sides of the house.

Roger Vercruysse said Spengler loved his mother, Arline, who died in October after living with her son and daughter in the house in a neighborhood of seasonal and year-round homes across the road from a lakeshore popular with recreational boaters.

As Pickering described it and as emergency radio communications on the scene showed, the heavily armed Spengler took a position behind a small hill by the house as four firefighters arrived after 5:30 a.m. to extinguish the fire: two on a fire truck; two in their own vehicles.

They were immediately greeted by bullets from Spengler, who wore dark clothing. Volunteer firefighter and police Lt. Michael Chiapperini, 43, driving the truck, was killed by gunfire as the windshield before him was shattered. Also killed was Tomasz Kaczowka, 19, who worked as a 911 dispatcher.

Several firefighters went beneath the truck to shield themselves as an off-duty police officer who was passing by pulled his vehicle alongside the truck to try to shield them, authorities said.

The first police officer who arrived chased and exchanged shots with Spengler, recounting it later over his police radio.

"I could see the muzzle blasts comin' at me. ... I fired four shots at him. I thought he went down," the officer said.

At another point, he said: "I don't know if I hit him or not. He's by a tree. ... He was movin' eastbound on the berm when I was firing shots." Pickering portrayed him as a hero who saved many lives.

The audio posted on the website RadioReference.com also has someone reporting "firefighters are down" and saying "got to be rifle or shotgun ? high-powered ... semi or fully auto."

Spengler had been charged with murder in his grandmother's death but pleaded guilty to a reduced charge of manslaughter, apparently to spare his family a trial. After he was freed from prison, Spengler ? a felon who wasn't allowed to possess weapons ? had lived a quiet life on Lake Road on a narrow peninsula where Irondequoit Bay meets Lake Ontario.

That ended when he left his burning home Monday morning, armed with his three weapons and a lot of ammunition.

"I'm not sure we'll ever know what was going through his mind," Pickering said.

___

Esch reported from Albany. Associated Press writer Larry Neumeister in New York City also contributed to this report.

Source: http://news.yahoo.com/firemens-killer-left-chilling-note-deaths-3-223847945.html

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LG brings sharper picture of its 2013 Google TV lineup launching at CES

After hinting in a Japanese press release that it'll out a bevy of new Google TV offerings in 2013, LG has firmed up the details, saying it'll launch seven new models at CES next January. Those include 42-, 57-, 50-, 55- and 60-inch models from the upcoming GA6400 series, along with 47- and 55-inch Cinema Screen panels included in the new GA7900 series. All the screens will ship with a redesigned Magic Qwerty Remote, which uses a full keyboard along with "natural language recognition" via a built-in microphone. Together with built-in Google search functions, that'll allow users to find "broadcast TV or internet content with only one vocal command," according to LG. Other features include the OnLive gaming platform app, a home dashboard to display other apps and content, LG's PrimeTime Quick Guide for browsing TV shows or movies, and a full browser. There's no word yet about pricing or availability, but hopefully that'll be one of the many, many morsels of info we'll be grabbing for you at CES 2013. Check the PR after the break for more info.

Continue reading LG brings sharper picture of its 2013 Google TV lineup launching at CES

Comments

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Sj7GPJmirVw/

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Best Alternative of Nose Surgery?

It is possible to get reshaped your nose without any surgery. Nose right proves an alternative to rhinoplasty, and it?s really effective. With the usage of nose right your nose can be small and becomes beautiful too. So I will suggest you to go for nose right and I m definitely sure that you will get 1oo% result. It?s cost is less and easily you can found it online.

_______________

nose right review

Source: http://www.elitefitness.com/forum/plastic-surgery/best-alternative-nose-surgery-1040403.html

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Chris Rea: Driving Home for Christmas

Right now, millions of people around the globe are desperately trying to make it home for Christmas. Some of those journeys will go smoothly; others will be completely frustrating. But, like Chris Rea sings, even if it takes some time, don't worry: you'll get there. Eventually. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/TQt4FydAOU4/chris-rea-driving-home-for-christmas

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Recruitment | Thomson Reuters GRC | Financial Crime Senior ...

The role of Senior Manager within the Financial Crime team entails providing compliance advice on regulatory issues and industry changes for a range of client engagements. The opportunity would enable you to play a key role in applying your financial crime knowledge and experience in helping clients to comply with regulatory requirements with regards to anti-money laundering and sanctions compliance.

The role would not only require you to carry out tasks to client specification, but would also necessitate establishing and maintaining strong and valued relationships with external clients and internal peers to develop a portfolio of business for the active identification of business opportunities.

As a respected senior professional and influential member of the team, you'll communicate effectively with all levels of staff, both in coaching and mentoring junior team members and in communicating effectively with engagement partners and managers to build, manage and motivate high-performing teams.

This excellent opportunity would enable you to apply and expand your compliance and regulatory knowledge and experience within a diverse role in a well-established and knowledgeable team.

Key Responsibilities

• Create innovative and proportionate insights for our financial crime clients, adapting methods and practices to fit their business needs
• Contribute to business development initiatives, including generating new business opportunities and building client networks and relationships
• Grow valued relationships with external clients and industry contacts
• Contribute to thought leadership - leveraging knowledge and experience to shape services to client needs
• Responsible for engagement planning, management, and leading and supervising teams in medium complex and elements of highly complex financial crime engagements
• You'll lead presentations bids and proposals for new projects and client opportunities, providing subject matter insight

Experience

• Substantial AML and / or sanctions work experience
• Strong technical knowledge of the UK, European and global financial crime regulatory environment
• Focus on one of the following sector specific areas: Wholesale Banking, Retail Banking, Investment Management, General Insurance
• Effective leadership, project management and teamwork skills for the scoping and delivery of financial crime engagements
• Strong stakeholder management and people skills, including a proven ability to manage multi-disciplinary teams and projects
• Financial Crime / AML professional qualification preferred
• Prior consulting experience highly desirable

If you feel you have the required skills and experience for this role then please forward your CV to danwise@jarvisblake.com or call 01322 611771 to find out more.

Source: http://www.complinet.com/recruitment/jobs/job/details/id/44038

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Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children

Public release date: 23-Dec-2012
[ | E-mail | Share ]

Contact: Kris Van der Beken
kris.vanderbeken@vib.be
32-473-783-435
VIB (the Flanders Institute for Biotechnology)

Acute lymphatic leukemia (ALL) is the most common cancer in children under the age of 14 years. With optimum treatment, approximately 75 % of children are currently cured, but the treatment consists of severe chemotherapy with many side effects. In collaboration with international research teams, scientists at VIB, KU Leuven and UZ Leuven have identified new genetic mutations that lead to T-ALL, a variant of ALL. They have unmasked the ribosome the molecular machine in the cell that is involved in the production of proteins as a weak spot in leukemia cells. Their research has also shown that there is a difference in T-ALL between adults and children. Both findings can be important in the search for improved treatments for T-ALL.

Jan Cools (VIB/KU Leuven):"We have discovered that there is a clear genetic difference between T-ALL in children and in adults. This could be an explanation why adults do not respond as well to the current therapy."

Stein Aerts (KU Leuven):"This is a beautiful example of the power of genome sequencing in cancer research. New technologies and large-scale bio-informatics allow us to study a lot of data simultaneously. This allows us to discover links that would have been impossible to find in the past."

T-cell acute lymphatic leukemia (T-ALL)

The formation of white blood cells is disrupted by leukemia. The cells in the bone marrow that should mature into white blood cells multiply unchecked without maturing completely. These immature blood cells compromise the production of normal blood cells. This makes patients more susceptible to infections. Leukemia occurs in different forms; in the case of T-ALL, there is an accumulation of immature white blood cells over a very short period of time. With optimum treatment involving chemotherapy approximately 75 % of children are currently cured. For adults, the chance of a cure is below 50 %. Chemotherapy is associated with many side effects. The search for a more specific treatment can only start once we know what causes T-ALL.

7 new genes with a key role in T-ALL identified

T-ALL only occurs if errors in various genes occur simultaneously. It is important to determine which genes play a key role. Kim De Keersmaecker, Zeynep Kalender Atak, Jan Cools and Stein Aerts have identified a series of defects in 15 important genes, of which 7 have not previously been associated with T-ALL. They used next-generation sequencing to analyze the 20,000+ genes of 67 T-ALL patients. This technique allows for very fast analysis and comparison of the complete DNA sequence of healthy and sick individuals.

A difference between adults and children

The investigators from Leuven also discovered a difference between T-ALL in children and in adults. T-ALL in adults contains significantly more mutations than in children. The leukemia cells in adults also contain mutations in other genes than in children. This genetic difference could be a possible explanation why adults do not respond as well to the current therapy.

A weak point in leukemia cells exposRPL5 and RPL10 two newly identified genes form A weak point in leukemia cells exposed

RPL5 and RPL10 two newly identified genes form part of the ribosome: this is the complex in the cell that produces proteins. The scientists hereby demonstrated for the first time that defects in the ribosome can also play a role in cancer activation. Experiments in yeast cells confirm that mutations in RPL10 cause a change in the ribosome.

Kim De Keersmaecker (VIB/KU Leuven):"This could be a weak point of the leukemia cells: all cells need properly functioning ribosomes to survive and to grow. These 'defective' ribosomes in the leukemia cells could be a new suitable target for the development of targeted therapies."

###

Patient information

As this study may raise many questions in patients, we would like to refer you to the e-mail address that the VIB has set up for this purpose. Anyone with questions about this research and other medical research can submit their questions on patients@vib.be. Please submit your question in Dutch or English only.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 23-Dec-2012
[ | E-mail | Share ]

Contact: Kris Van der Beken
kris.vanderbeken@vib.be
32-473-783-435
VIB (the Flanders Institute for Biotechnology)

Acute lymphatic leukemia (ALL) is the most common cancer in children under the age of 14 years. With optimum treatment, approximately 75 % of children are currently cured, but the treatment consists of severe chemotherapy with many side effects. In collaboration with international research teams, scientists at VIB, KU Leuven and UZ Leuven have identified new genetic mutations that lead to T-ALL, a variant of ALL. They have unmasked the ribosome the molecular machine in the cell that is involved in the production of proteins as a weak spot in leukemia cells. Their research has also shown that there is a difference in T-ALL between adults and children. Both findings can be important in the search for improved treatments for T-ALL.

Jan Cools (VIB/KU Leuven):"We have discovered that there is a clear genetic difference between T-ALL in children and in adults. This could be an explanation why adults do not respond as well to the current therapy."

Stein Aerts (KU Leuven):"This is a beautiful example of the power of genome sequencing in cancer research. New technologies and large-scale bio-informatics allow us to study a lot of data simultaneously. This allows us to discover links that would have been impossible to find in the past."

T-cell acute lymphatic leukemia (T-ALL)

The formation of white blood cells is disrupted by leukemia. The cells in the bone marrow that should mature into white blood cells multiply unchecked without maturing completely. These immature blood cells compromise the production of normal blood cells. This makes patients more susceptible to infections. Leukemia occurs in different forms; in the case of T-ALL, there is an accumulation of immature white blood cells over a very short period of time. With optimum treatment involving chemotherapy approximately 75 % of children are currently cured. For adults, the chance of a cure is below 50 %. Chemotherapy is associated with many side effects. The search for a more specific treatment can only start once we know what causes T-ALL.

7 new genes with a key role in T-ALL identified

T-ALL only occurs if errors in various genes occur simultaneously. It is important to determine which genes play a key role. Kim De Keersmaecker, Zeynep Kalender Atak, Jan Cools and Stein Aerts have identified a series of defects in 15 important genes, of which 7 have not previously been associated with T-ALL. They used next-generation sequencing to analyze the 20,000+ genes of 67 T-ALL patients. This technique allows for very fast analysis and comparison of the complete DNA sequence of healthy and sick individuals.

A difference between adults and children

The investigators from Leuven also discovered a difference between T-ALL in children and in adults. T-ALL in adults contains significantly more mutations than in children. The leukemia cells in adults also contain mutations in other genes than in children. This genetic difference could be a possible explanation why adults do not respond as well to the current therapy.

A weak point in leukemia cells exposRPL5 and RPL10 two newly identified genes form A weak point in leukemia cells exposed

RPL5 and RPL10 two newly identified genes form part of the ribosome: this is the complex in the cell that produces proteins. The scientists hereby demonstrated for the first time that defects in the ribosome can also play a role in cancer activation. Experiments in yeast cells confirm that mutations in RPL10 cause a change in the ribosome.

Kim De Keersmaecker (VIB/KU Leuven):"This could be a weak point of the leukemia cells: all cells need properly functioning ribosomes to survive and to grow. These 'defective' ribosomes in the leukemia cells could be a new suitable target for the development of targeted therapies."

###

Patient information

As this study may raise many questions in patients, we would like to refer you to the e-mail address that the VIB has set up for this purpose. Anyone with questions about this research and other medical research can submit their questions on patients@vib.be. Please submit your question in Dutch or English only.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-12/vfi-rsn122012.php

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